Rheological characterization of an injectable alginate gel system

BMC Biotechnology

Benjamin Endré Larsen³  Jorunn Bjørnstad⁴  Erik Olai Pettersen¹  Hanne Hjorth Tønnesen³  Jan Egil Melvik² 

[1] Department of Physics, University of Oslo, Oslo, Norway

[2] Current address: Origomar AS, Oslo, Norway

[3] School of Pharmacy, University of Oslo, Oslo, Norway

[4] Current address: Elopak AS, Spikkestad, Norway

关键词: Rheological characterization;    Gel system;    Gelling kinetics;    Biocompatible;    Alginate gel;   

Others  :  1210263
DOI  :  10.1186/s12896-015-0147-7

 received in 2014-07-18, accepted in 2015-04-21,  发布年份 2015

【 摘 要 】

Background

This work investigates a general method for producing alginate gel matrices using an internal mode of gelation that depends solely on soluble alginate and alginate/gelling ion particles. The method involves the formulation of two-component kits comprised of soluble alginate and insoluble alginate/gelling ion particles. Gelling kinetics, elastic and Young’s moduli were investigated for selected parameters with regard to soluble alginate guluronate content, molecular weight, calcium or strontium gelling ions and alginate gelling ion particle sizes in the range between 25 and 125 micrometers.

Results

By mixing the two components and varying the parameters mentioned above, alginate gel matrices with tailor-made viscoelastic properties and gelling kinetics were obtained. Final gel elasticity depended on alginate type, concentration and gelling ion. The gelling rate could be manipulated, e.g. through selection of the alginate type and molecular weight, particle sizes and the concentration of non-gelling ions.

Conclusions

Formulations of the injectable and moldable alginate system presented have recently been used within specific medical applications and may have potential within regenerative medicine or other fields.

【 授权许可】

   
2015 Larsen et al.; licensee BioMed Central.

【 图 表 】

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