BAIAP2 exhibits association to childhood ADHD especially predominantly inattentive subtype in Chinese Han subjects

Behavioral and Brain Functions

Lu Liu¹  Li Sun¹  Ze-Hua Li¹  Hai-Mei Li¹  Li-Ping Wei²  Yu-Feng Wang¹  Qiu-Jin Qian¹ 

[1] Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China

[2] Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China

关键词: Subtype;    Hemispheric asymmetry;    BAIAP2;    Attention-deficit/hyperactivity disorder (ADHD);   

Others  :  792038
DOI  :  10.1186/1744-9081-9-48

 received in 2013-09-02, accepted in 2013-12-27,  发布年份 2013

【 摘 要 】

Background

Attention-deficit/hyperactivity disorder (ADHD) is a common chronic neurodevelopmental disorder with a high heritability. Much evidence of hemisphere asymmetry has been found for ADHD probands from behavioral level, electrophysiological level and brain morphology. One previous research has reported possible association between BAIAP2, which is asymmetrically expressed in the two cerebral hemispheres, with ADHD in European population. The present study aimed to investigate the association between BAIAP2 and ADHD in Chinese Han subjects.

Methods

A total of 1,397 ADHD trios comprised of one ADHD proband and their parents were included for family-based association tests. Independent 569 ADHD cases and 957 normal controls were included for case-control studies. Diagnosis was performed according to the DSM-IV criteria. Nine single nucleotide polymorphisms (SNPs) of BAIAP2 were chosen and performed genotyping for both family-based and case-control association studies.

Results

Transmission disequilibrium tests (TDTs) for family-based association studies showed significant association between the CA haplotype comprised by rs3934492 and rs9901648 with predominantly inattentive type (ADHD-I). For case-control study, chi-square tests provided evidence for the contribution of SNP rs4969239, rs3934492 and rs4969385 to ADHD and its two clinical subtypes, ADHD-I and ADHD-C. However, only the associations for ADHD and ADHD-I retained significant after corrections for multiplicity or logistic regression analyses adjusting the potential confounding effect of gender and age.

Conclusions

These above results indicated the possible involvement of BAIAP2 in the etiology of ADHD, especially ADHD-I.

【 授权许可】

   
2013 Liu et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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