期刊论文详细信息
Arthritis Research & Therapy
Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with fibromyalgia
Guoqiang Yu4  Charlotte A Peterson2  Leslie J Crofford1  Ratchakrit Srikuea5  Douglas Long2  Brock Symons3  Katelyn Gurley4  Yu Shang4 
[1]Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
[2]College of Health Sciences, University of Kentucky, Lexington, KY 40536, USA
[3]Department of Gerontology, College of Public Health, University of Kentucky, Lexington, KY 40536, USA
[4]Center for Biomedical Engineering, University of Kentucky, Lexington, KY 40506, USA
[5]Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
Others  :  799778
DOI  :  10.1186/ar4079
 received in 2012-05-16, accepted in 2012-10-25, published in 14
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【 摘 要 】

Introduction

Women with fibromyalgia (FM) have symptoms of increased muscular fatigue and reduced exercise tolerance, which may be associated with alterations in muscle microcirculation and oxygen metabolism. This study used near-infrared diffuse optical spectroscopies to noninvasively evaluate muscle blood flow, blood oxygenation and oxygen metabolism during leg fatiguing exercise and during arm arterial cuff occlusion in post-menopausal women with and without FM.

Methods

Fourteen women with FM and twenty-three well-matched healthy controls participated in this study. For the fatiguing exercise protocol, the subject was instructed to perform 6 sets of 12 isometric contractions of knee extensor muscles with intensity steadily increasing from 20 to 70% maximal voluntary isometric contraction (MVIC). For the cuff occlusion protocol, forearm arterial blood flow was occluded via a tourniquet on the upper arm for 3 minutes. Leg or arm muscle hemodynamics, including relative blood flow (rBF), oxy- and deoxy-hemoglobin concentration ([HbO2] and [Hb]), total hemoglobin concentration (THC) and blood oxygen saturation (StO2), were continuously monitored throughout protocols using a custom-built hybrid diffuse optical instrument that combined a commercial near-infrared oximeter for tissue oxygenation measurements and a custom-designed diffuse correlation spectroscopy (DCS) flowmeter for tissue blood flow measurements. Relative oxygen extraction fraction (rOEF) and oxygen consumption rate (rVO2) were calculated from the measured blood flow and oxygenation data. Post-manipulation (fatiguing exercise or cuff occlusion) recovery in muscle hemodynamics was characterized by the recovery half-time, a time interval from the end of manipulation to the time that tissue hemodynamics reached a half-maximal value.

Results

Subjects with FM had similar hemodynamic and metabolic response/recovery patterns as healthy controls during exercise and during arterial occlusion. However, tissue rOEF during exercise in subjects with FM was significantly lower than in healthy controls, and the half-times of oxygenation recovery (Δ[HbO2] and Δ[Hb]) were significantly longer following fatiguing exercise and cuff occlusion.

Conclusions

Our results suggest an alteration of muscle oxygen utilization in the FM population. This study demonstrates the potential of using combined diffuse optical spectroscopies (i.e., NIRS/DCS) to comprehensively evaluate tissue oxygen and flow kinetics in skeletal muscle.

【 授权许可】

   
2012 Shang et al.; licensee BioMed Central Ltd.

【 预 览 】
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