Ugi/Palladium-Catalysed Intramolecular Cyclopropyl Direct Alkenylation Cascade Reaction Providing Access to Azacycles

2018 3rd International Conference on Insulating Materials, Material Application and Electrical Engineering

材料科学;无线电电子学;电工学

Shang, Tianyi^1 ; Liu, Yan^1

School of Biological and Pharmaceutical Engineering, Xinyang Agriculture and Forestry University, Xinyang, China^1

关键词: C-H bond;    Cascade reactions;    Cyclopropyl;    High-efficiency;    One pot;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/452/2/022128/pdf
DOI  :  10.1088/1757-899X/452/2/022128

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

A novel example of Ugi/Palladium-catalyzed intramolecular cyclopropyl direct alkenylation cascade reaction providing access to novel azacycles in one pot has been developed. Palladium-catalysed direct alkenylation of cyclopropyl C-H bonds proceeds in high efficiency with easy work-up. This transformation was adjusted by 2-substituent on cyclopropyl providing alternative access to cyclopropyl-fused azacycles or ring-expending products.