Study on the Preparation Technology of Sanqi Shangyao Pasters for Percutaneous Absorption

2018 3rd International Conference on Insulating Materials, Material Application and Electrical Engineering

材料科学;无线电电子学;电工学

Liu, Shijun^1,2,3 ; Zhang, Pan^1,2,3 ; Tang, Zhishu^1,2,3 ; Zhang, Yu^1,2,3 ; Song, Zhongxing^1,2,3 ; Cui, Chunli^1,2,3 ; Liu, Hongbo^1,2,3 ; Xu, Hongbo^1,2,3 ; Ma, Baozhu^1,2,3

Shaanxi University of Chinese Medicine, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Xianyang, Shaanxi

712083, China^1

Shaanxi Research Centre on Discovery and Innovation of New Medicine, Xianyang, Shaanxi

712083, China^2

Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Xianyang, Shaanxi

712083, China^3

关键词: Cold resistance;    Dosage forms;    Orthogonal test;    Penetration enhancers;    Percutaneous absorption;    Preparation technology;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/452/2/022140/pdf
DOI  :  10.1088/1757-899X/452/2/022140

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Objective: The dosage form of Sanqi Shangyao tablets was reformed and made the pastes. Methods: Starch and Zinc oxide were used as the excipients of the pastes. Glycerol was used as a wetting agent and lauriazone was used as a penetration enhancer. On the basis of the single factor test, the orthogonal test L9 (33) was used to screen the matrix prescription. The best proportion of the matrix prescription were obtained by investigating the viscosity, heat resistance and cold resistance test, skin tactility and fluidity of the pastes matrix. Results: The best formula for screening was the total dosage of starch and Zinc oxide was 6.0 g (2:1), glycerol dosage was 2.0 g, and the dosage of Azone was 0.3 g. Conclusion: The pastes obtained by orthogonal test is better in the aspects of stickiness, heat resistance, cold resistance, skin touch, and fluidity, and the preparation of the Sanqi Shangyao pasters is simple and feasible.