Synthesis, biodegradability, and drug delivery property of apatite/gelatin composite microspheres

2018 International Conference on Advanced Electronic Materials, Computers and Materials Engineering

材料科学;无线电电子学;计算机科学

Zhang, Jing^1 ; Yao, Yunhong^1 ; Wei, Aili^1 ; Shen, Lulu^1 ; Chen, Song^1

College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, Shanxi

030024, China^1

关键词: Biodegra-dable materials;    Composite microspheres;    Drug delivery system;    Fourier transform infra reds;    Phosphate buffer salines;    Sustained drug release;    Tetracycline hydrochloride;    X ray diffractometers;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/439/4/042009/pdf
DOI  :  10.1088/1757-899X/439/4/042009

来源: IOP

【 摘 要 】

Biodegradable materials are of great importance in the development of novel drug delivery system. Here, the apatite/gelatin composite microspheres were synthesized as the mixture of apatite and gelatin was emulsified in the plant oil and then cross-linked with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide. Their biodegradability and drug delivery property were evaluated. The resultant microspheres were characterized with an optical microscope, a scanning electron microscope, a transmission electron microscope, an X-ray diffractometer and a Fourier transform infrared spectroscope. The results have indicated that the as-synthesized microspheres were spherical in shape and had a size range of 50-230 μm. After soaked in the phosphate buffer saline (pH = 7.4), the composite microspheres were biodegradable and their biodegradation rate approximated 28 ± 2% after 14 days of incubation. It was further found that the present composite microspheres could support the encapsulation of tetracycline hydrochloride as model drug and presented a sustained drug release behavior.