Poly (Terephthaloyl Diglyceride-co-1, 2-cyclohexanediacyl Diglyceride) - A Biodegradable and Biocompatible Functional Polymer for Biomedical Applications

2018 3rd International Conference on Advanced Materials Research and Manufacturing Technologies

材料科学;机械制造

Xie, Yangfen^1 ; Sun, Lijie^2 ; Bi, Xiaoping^3,4 ; Guo, Yifan^2 ; Chen, Shuo^2 ; Fan, Xianqun^3,4 ; Qing, Fengling^1 ; You, Zhengwei^2

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Shanghai

201620, China^1

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai

201620, China^2

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University, School of Medicine, No.639 Zhizaoju Road, Shanghai

200011, China^3

Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai

200011, China^4

关键词: Biodegradable polyesters;    Biomedical applications;    Copolyesters;    Cytocompatibility;    Diglyceride;    Epoxide ring-opening polymerization;    Free hydroxyl groups;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/436/1/012008/pdf
DOI  :  10.1088/1757-899X/436/1/012008

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Biodegradable polyesters have been widely used in biomedical engineering. Introduction of functional groups to polyesters will expand their applications. Herein, we developed a functionalizable copolyester with free hydroxyl groups (-OH) - poly (terephthaloyl diglyceride-co-1,2-cyclohexanediacyl diglyceride) (PTeCD). PTeCD was readily synthesized by acid-induced epoxide ring-opening polymerization in one step. Its structure was characterized by NMR and FTIR. PTeCD exhibited a good cytocompatibility and biodegradability. We expect PTeCD will be a useful polymer for biomedical applications.