Potential Therapeutic Activity of Bio-Synthesized Silver Nanoparticles as Anticancer and Antimicrobial Agent

1st International Conference on Advanced Engineering Functional Materials

Basak, Piyali^1 ; Majumder, Ranabir^1 ; Jasu, Amrita^1 ; Paul, Samrat^1 ; Biswas, Shreya^1

School of Bioscience and Engineering, Jadavpur University, Kolkata

700032, India^1

关键词: Alovera;    Anti-microbial activity;    Anti-oxidant activities;    Breast cancer cells;    Green chemistry approaches;    Pharmacological properties;    Reduction of silver nitrates;    Synthesised;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/410/1/012020/pdf
DOI  :  10.1088/1757-899X/410/1/012020

来源: IOP

【 摘 要 】

Aloevera is one of the oldest medicinal plants and it possesses different types of pharmacological properties including anti-microbial, anti-inflammatory, anti-cancer and antioxidant activity. More over Aloevera contains 75 bioactive compounds such as polyphenol, flavonoids, alkaloids, anthraquinone etc. Such bioactive compounds can be used to reduce silver ions to produce silver nanoparticles. In this study, we are trying to formulate bio-synthesised silver nanoparticle (b-AgNps) by green chemistry approach. It is a very simple, efficient and eco-friendly approach for silver nanoparticle synthesis that is formed by reduction of silver nitrate (AgNO3) solution using Aloe vera leaf extract as a reducing agent. Hydrothermal method was used to prepare b-AgNps using aloe vera leaf extract as both reducing and stabilizing agent. Then b-AgNps were characterized by FESEM, XRD, DLS and UV-VIS spectroscopy. Biological activity of b-AgNps were evaluated by performing cytotoxic test (MTT assay) against breast cancer cell lines and Fibroblast normal cell lines as well as screening antimicrobial activity using agar well diffusion method. The results revealed that there was significant amount of cell growth inhibition against breast cancer cell lines as well as microbes compare to normal healthy fibroblast cell lines.