The Biocompatibility Comparison of Modified Polysulfone by 2-Methoxyethylacrylate and the Sulfonated Hydroxypropyl Chitosan

2018 5th International Conference on Advanced Composite Materials and Manufacturing Engineering

Xu, Jingjie^1 ; Li, Ming^1 ; Tang, Shuyun^1 ; Qiu, Yunren^1

School of Chemistry and Chemical Engineering, Central South University, Changsha

410083, China^1

关键词: 2-methoxyethylacrylate;    Biomedical material;    Hydroxypropyl chitosans;    Michael addition reactions;    Polysulfone membranes;    Schiff base reaction;    Water contact angle;    Water contact angle (WCA);   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/394/2/022039/pdf
DOI  :  10.1088/1757-899X/394/2/022039

来源: IOP

【 摘 要 】

In this paper, polysulfone materials were modified with 2-methoxyethylacrylate and the sulfonated hydroxypropyl chitosan in different graft method respectively. After being through chloromethylation and amination reaction of polysulfone, polysulfone-graft-poly (2-methoxyethylacrylate) (PSF-g-PMEA) was synthesized via Michael addition reaction, while the sulfonated hydroxypropyl chitosan (SHPCS) was grafted from polysulfone membrane material by Schiff-Base reaction. Scanning electron microscopy (SEM), water contact angles (WCA) measurement, protein adsorptions, hemolysis assay of the membranes were characterized and tested. The results showed that the water contact angle of modified polysulfone materials decreased to 60.5 °C and 31.8 °C, and the amount of protein adsorption declined at least 83.3%. Furthermore, the hemolysis ratios changed from 2.89% to 1.08%. All of results exhibited that modified polysulfone membrane materials have better biocompatibility than pure polysulfone materials and have potential application in biomedical materials.