Compaction behaviour and mechanical strength of lactose-sodium starch glycolate and lactose-croscarmellose sodium binary tablets

International Conference on Innovative Technology, Engineering and Sciences 2018

工业技术;自然科学

Yaakub, Nur Ashikin^1 ; Anuar, Mohd Shamsul^1 ; Tahir, Suraya Mohd^2

Department of Process and Food Engineering, Faculty of Engineering, Universiti Putra Malaysia, UPM Serdang, Selangor

43400, Malaysia^1

Department of Mechanical and Manufacturing Engineering, Faculty of Engineering, Universiti Putra Malaysia, UPM Serdang, Selangor

43400, Malaysia^2

关键词: Compaction pressure;    Die cavity;    Disintegrant;    Experimental conditions;    Mass composition;    Plastic energy;    Sodium starch glycolate;    Uniaxial die compaction;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/342/1/012026/pdf
DOI  :  10.1088/1757-899X/342/1/012026

来源: IOP

【 摘 要 】

The focus of this study is to elucidate the effects of adding super disintegrants (SSG and Acdisol) to a filler (lactose) in terms of the compaction behaviour and mechanical strength of the formed binary tablets. The tablets were formed in a uniaxial die compaction process with compaction pressures ranging from 37.7MPa to 150.7 MPa. Consequently, the findings indicated that the increasing of the compaction pressure and the percentage mass composition of the super disintegrants would led to the increased in the strength of the tablets as well as their plastic energies, where this was more apparent for the case of the binary lactose/Acdisol tablets. In addition, as the compaction pressure increased, the maximum ejection pressure required to eject the tablet from the die cavity also increased. In contrast, a decreased in the maximum ejection pressure was observed as the composition of both super disintegrants increased in the lactose-super disintegrant binary tablets. In conclusion, the addition of super disintegrant; SSG with lactose and Acdisol with lactose; would enhanced the mechanical strength of lactose based tablets especially for the case of acdisol-lactose binary tablets in the experimental conditions adopted in this current work.