The effect of hydrochloric acid addition to increase carbon nanotubes dispersibility as drug delivery system by covalent functionalization

Quality in Research: International Symposium on Materials, Metallurgy, and Chemical Engineering

材料科学;冶金学;化学工业

Wulan, P.P.D.K.^1,3 ; Ulwani, S.H.^2 ; Wulandari, H.^2 ; Purwanto, W.W.^3 ; Mulia, K.^3

Research Center for Biomedical Engineering, Faculty of Engineering, University of Indonesia, Depok

16424, Indonesia^1

Sustainable Energy Laboratory, Chemical Engineering Department, Faculty of Engineering, University of Indonesia, Depok

16424, Indonesia^2

Chemical Engineering, Faculty of Engineering, University of Indonesia, Depok

16424, Indonesia^3

关键词: Covalent functionalizations;    Dispersibilities;    Dispersion time;    Drug delivery system;    FT-IR spectrum;    Functionalizations;    Hydroxyl groups;    Potential values;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/316/1/012013/pdf
DOI  :  10.1088/1757-899X/316/1/012013

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

This study is to obtain the effect of adding hydrochloric acid (HCl) to the mixture of sulfuric acid (H2SO4) and HNO3in CNT covalent functionalization. HCl expected to increase the dispersibility of functionalized CNT by improving the dispersion time period done with H2SO4or HNO3. Functionalization used mixture of H2SO4and HNO3with volume ratio of 3:1. Covalent functionalization used 0.5 grams of MWCNT ultra sonicated in 50mL HNO3with and mixture of H2SO4and HNO3. Additions of 200 mL HCl used variation of molarity from 1M, 2M, 3M, 4M, 5M to 6M. CNT were oxidized to form carboxylic and hydroxyl bonds on the surface that increase dispersibility of CNT. FTIR spectrums showed the existences of carboxyl and hydroxyl group on spectra of 2600-3700 cm-1and 900-1400 cm-1. Dispersion tests, which showed functionalized CNT (f-CNT) dispersion capabilities, were done by dissolving f-CNT in water. The study resulted that 6M f-CNT (NSC6) gave the best dispersion with zeta potential value of -37.1mV. NSC6 gave the longest dispersion time which was 20 days until f-CNT settle again. SEM-EDS micrographs showed the surface structure of 6M f-CNT without significant damage and no longer contain impurities of Fe, Ni, and Cl.