Determination of Parabens by Injection-Port Derivatization Coupled With Gas-Chromatography-Mass Spectrometry and Matrix Solid Phase Dispersion

International Conference on Chemistry and Material Science 2017

化学;材料科学

Djatmika, Rosalina^1,2,3 ; Ding, Wang-Hsien^2 ; Sulistyarti, Hermin^3

Department of Pharmacy, Sekolah Tinggi Ilmu Kesehatan Karya Putra Bangsa, Jl. Raya Tulungagung-Blitar KM 4, Tulungagung, Indonesia^1

Department of Chemistry, National Central University, 300 Jhong-Da Road, Jhong-Li, Taoyuan, Taiwan^2

Depertment of Chemistry, Faculty of Mathematics and Natural Sciences, Brawijaya University, Jl. Veteran 65145, Malang, Indonesia^3

关键词: Acetic anhydrides;    Elution solvent;    Environmental-friendly;    Gas chromatography-mass spectrometries (GC-MS);    Gas chromatography-mass spectrometry;    Limits of quantitations;    Matrix solid phase dispersion (MSPD);    Sample processing;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/299/1/012005/pdf
DOI  :  10.1088/1757-899X/299/1/012005

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

A rapid determination of four parabens preservatives (methyl paraben, ethyl paraben, propyl paraben, and butyl paraben) in marketed seafood is presented. Analytes were extracted and purified using matrix solid-phase dispersion (MSPD) method, followed by Injection port acylation gas chromatography-mass spectrometry (GC-MS) with acetic anhydride reagent. In this method, acylation of parabens was performed by acetic anhydride at GC injection-port generating reduction of the time-consuming sample-processing steps, and the amount of toxic reagents and solvents. The parameters affecting this method such as injection port temperature, purge-off time and acylation (acetic anhydride) volume were studied. In addition, the MSPD influence factors (including the amount of dispersant and clean-up co-sorbent, as well as the volume of elution solvent) were also investigated. After MSPD method and Injection port acylation applied, good linearity of analytes was achieved. The limits of quantitation (LOQs) were 0.2 to 1.0 ng/g (dry weight). Compared with offline derivatization commonly performed, injection port acylation employs a rapid, simple, low-cost and environmental-friendly derivatization process. The optimized method has been successfully applied for the analysis of parabens in four kind of marketed seafood. Preliminary results showed that the total concentrations of four selected parabens ranged from 16.7 to 44.7 ng/g (dry weight).