Synthesize of zinc nanoparticles using Indonesian velvet bean (Mucuna pruriens) extract and evaluate its potency in lowering catalepsy in mice

International Conference on Chemistry and Material Science 2017

化学;材料科学

Sardjono, Ratnaningsih Eko^1 ; Khoerunnisa, Fitri^1 ; Musthopa, Iqbal^1 ; Khairunisa, Dinar^1 ; Suganda, Putri Astuti^1 ; Rachmawati, Rahmi^1

Department of Chemistry, Faculty of Mathematics and Natural Science Education, Universitas Pendidikan Indonesia, Jalan Setiabudi No. 229, Bandung

40154, Indonesia^1

关键词: antiparkinson;    catalepsy;    Energy dispersive X ray spectroscopy;    Fourier transform infrared;    Mucuna pruriens;    Velvet bean;    Zinc acetate dihydrate;    Zinc nanoparticles;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/299/1/012080/pdf
DOI  :  10.1088/1757-899X/299/1/012080

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

This study aims to synthesize zinc nanoparticles using Indonesian velvet bean (Mucuna pruriens) seed extract and evaluate its potency in lowering catalepsy in mice. The research conducted consist of extraction of M. pruriens seed powder, synthesis of zinc-M. pruriens seed extract nanoparticles (Zn-MPn), characterization of Zn-MPn, and catalepsy test of Zn-MPn. M. pruriens seed powder was extracted by maceration using ethanol-water (1:1) at pH 3 adjusted with citric acid. The Zn-MPn was synthesized by reacting zinc acetate dihydrate (Zn(CH3COO2)2.2H2O) solution with M. pruriens seed extract for 40 min, dispersibility of the reaction was controlled by using sonication and ultrasonic homogenizer. The Zn-MPn obtained was characterized by scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX), transmission electron microscopy (TEM), and Fourier-transform infrared (FTIR). Catalepsy test of Zn-MPn was conducted at doses of 5, 10, 15, 20 and 25 mg/kg body weight. The results of SEM-EDX and TEM analysis showed that the Zn-MPn formed nanoparticles with a particle diameter of 55 nm. Based on FTIR analysis, the absorption band at 464.8 cm-1was a typical absorption indicated the Zn-O interaction on Zn-MPn. Catalepsy test showed that Zn-MPn on the all five doses were able to lower the catalepsy in mice with the best dose was 10 mg/kg body weight.