Understanding the significance variables for fabrication of fish gelatin nanoparticles by Plackett-Burman design

International Conference on Advances in Manufacturing and Materials Engineering 2017

机械制造;材料科学

Subara, Deni^1 ; Jaswir, Irwandi^1,2 ; Rashid Alkhatib, Maan Fahmi^1 ; Noorbatcha, Ibrahim Ali^1

Department of Biotechnology Engineering, Faculty of Engineering, International Islamic University Malaysia, Kuala Lumpur

53100, Malaysia^1

International Institute for Halal Research and Training (INHART), International Islamic University Malaysia Gombak, Kuala Lumpur, Malaysia^2

关键词: Cross-linkers;    Fish gelatin;    Particles sizes;    Plackett-Burman designs;    Process Variables;    Quality by designs;    Quality design;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/290/1/012006/pdf
DOI  :  10.1088/1757-899X/290/1/012006

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

The aim of this experiment is to screen and to understand the process variables on the fabrication of fish gelatin nanoparticles by using quality-design approach. The most influencing process variables were screened by using Plackett-Burman design. Mean particles size, size distribution, and zeta potential were found in the range 240°9.76 nm, 0.3, and -9 mV, respectively. Statistical results explained that concentration of acetone, pH of solution during precipitation step and volume of cross linker had a most significant effect on particles size of fish gelatin nanoparticles. It was found that, time and chemical consuming is lower than previous research. This study revealed the potential of quality-by design in understanding the effects of process variables on the fish gelatin nanoparticles production.