Analysis of structure of hyperfine poly(3-hydroxybutyrate) fibers (PHB) for controlled drug delivery

International Conference "Modern Technologies and Materials of New Generations"

Olkhov, A.A.^1,3 ; Kosenko, R. Yu^3 ; Markin, V.S.^3 ; Zykova, A.K.^1,2 ; Pantyukhov, P.V.^1,2 ; Karpova, S.G.^2 ; Iordanskii, A.L.^3

Department of Chemistry and Physics, Plekhanov Russian University of Economics, 36 Stremyanny Lane, Moscow

117997, Russia^1

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 Kosygina Street, Moscow

119334, Russia^2

Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 Kosygina Street, Moscow

119334, Russia^3

关键词: Cylindrical fibers;    Diffusive transport;    Electrospinning method;    Encapsulated drugs;    Fibrous material;    Geometrical shapes;    Poly-3-hydroxybutyrate;    Structural characteristics;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/286/1/012033/pdf
DOI  :  10.1088/1757-899X/286/1/012033

来源: IOP

【 摘 要 】

Hyperfine fibers based on biodegradable poly (3-hydroxybutyrate) with encapsulated drug substance (dipyridamol) were obtained by using electrospinning method. Addition of dipyridamol has a significant effect on geometrical shape and structure of microfibers as well as total porosity of fibrous material. Observation of fibers using scanning electron microscopy (SEM) method showed that without or at lower dipyridamol content (