The influence of black cumin seed oil therapy with dosage of 1.5 mL/day and 3 mL/day to interleukin-21 (IL-21) expression of the patients with metabolic syndrome risk

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Fajar, D.R.^1 ; Akrom^1,2 ; Darmawan, E.^1

Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia^1

Center of Drug Information and Study, Universitas Ahmad Dahlan, Yogyakarta, Indonesia^2

关键词: Antioxidant enzyme;    Interleukin-21;    Metabolic disorders;    Metabolic syndromes;    Pancreatic beta cells;    Pro-inflammatory cytokines;    Reactive oxygen species;    Seed oil;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/259/1/012012/pdf
DOI  :  10.1088/1757-899X/259/1/012012

来源: IOP

【 摘 要 】

Metabolic syndrome (MS) is a metabolic disorder caused by obesity and insulin resistance. In the state of obesity and insulin resistance occurs increased fat metabolism that causes production reactive oxygen species (ROS) and oxidative stress that makes dysregulation of adipose tissue that decreases antioxidant enzymes and immune system disorders. In diabetes mellitus there is pancreatic β cell damage caused by pro-inflammatory cytokines i.e interleukin-21 (IL-21). Black cumin seed oil (BCSO) contains antioxidants and immunomodulators but has not seen how it affects to IL-21. This study used cross over design to determine the effect of BCSO with dose of 1.5 mL/day and 3 mL/day dose of IL-21 in MS patients. The total subjects 66 of MS patients were divided into 2 groups. Group I was administered 1.5 mL/day and 3 mL/day of BCSO in dosage for 20 days and continued with washing out (BCSO discontinued) for 7 days. On the day 28, group I administrated 3 mL/day of BCSO and group II were given 1.5 mL/day of BCSO during 20 days. Statistical analysis showed that mean value expression of IL-21 were given by BCSO at dose 1.5 mL/day was 5.06±5.48 and BCSO at dose 3 mL/day 4.66±3.63 (p