GC-MS analysis and antimicrobial activity determination of Citrus medica L. var proper leaf essential oil from South Sulawesi against skin pathogen microorganism

International Pharmacy Conference UAD 2017 on Product Authentication: Key Factor in Quality Control of Pharmaceutical Products

Aliyah^1 ; Himawan, A.^1 ; Rante, H.^1 ; Mufidah^1 ; Ningsih, D.R.^1

Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia^1

关键词: Anti-microbial activity;    antimicrobial;    Candida albicans;    Citrus medica L. var Proper;    extract;    Leaf essential oil;    Propionibacterium acnes;    Staphylococcus aureus;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/259/1/012001/pdf
DOI  :  10.1088/1757-899X/259/1/012001

来源: IOP

【 摘 要 】

A research about Citrus medica L. var sarcodactylis had been conducted and it showed a significant antimicrobial activity, thus drive our curiosity to investigate the other variety from the same species, Citrus medica L. var proper. This research focuses in chemical compound study and antimicrobial activity screening against Staphylococcus aureus, Propionibacterium acne, and Candida albicans of Citrus medica L. var Proper leaves' essential oil. The essential oil is distillated from fresh leaves by hydrodestillation. The chemical compound was analysed using GC-MS instrument while the antimicrobial activity was tested using disk diffusion method. The results showed that the major component of the essential oil was Z-citral, citral and limonene compounds. The antimicrobial activity test results against the test microorganism are 9.15±0.15 mm, 11.15±1.3 mm and 8.02±0.48 mm, consecutively, for Staphylococcus aureus, Propionibacterium acne and Candida albicans.