Peculiarities of living cell response to the external stimuli revealed via quasistatic mode of atomic force microscopy

Scanning Probe Microscopy 2017

Khalisov, M.M.^1,2 ; Ankudinov, A.V.^2,3 ; Penniyaynen, V.A.^1 ; Timoshenko, T.E.^1 ; Timoshchuk, K.I.^2 ; Samsonov, M.V.^4 ; Shirinsky, V.P.^4

Pavlov Institute of Physiology RAS, Saint Petersburg

199034, Russia^1

ITMO University, Saint Petersburg

197101, Russia^2

Ioffe Institute, Saint Petersburg

194021, Russia^3

National Cardiology Medical Research Center, Moscow

121552, Russia^4

关键词: External influences;    External stimulus;    Living cell;    Quasi-static modes;    Sensory neurons;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/256/1/012010/pdf
DOI  :  10.1088/1757-899X/256/1/012010

来源: IOP

【 摘 要 】

The technique of atomic force microscopy allows revealing living cell morphology and mechanical properties characterization under physiologically relevant conditions. Here, we review our recent results on living cell reaction to different external influences obtained by this technique. The Bruker PeakForce QNM quasistatic mode was used to study living fibroblasts, erythrocytes, sensory neurons, and endothelial cells.