Micro-Encapsulated Porphyrins and Phthalocyanines _ New Formulations in Photodynamic Therapy

International Conference on Innovative Research - ICIR Euroinvent 2017

Ion, R.M.^1,2

Nanomedicine Department, ICECHIM, 202 Splaiul Independentei, Buicharest

060021, Romania^1

Department of Engineering Doctoral Studies, Valahia University, 13 Aleea Sinaia, Targoviste, Romania^2

关键词: Controlled releasing;    Encapsulated porphyrin;    Ionic crosslinking;    Photochemical mechanism;    Photodynamic therapy (PDT);    Reactive oxygen species;    Singlet oxygen generation;    Spectroscopic property;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/209/1/012010/pdf
DOI  :  10.1088/1757-899X/209/1/012010

来源: IOP

【 摘 要 】

Photodynamic therapy (PDT), as an innovative method for cancer tretament is based on a concerted action of some drugs, called sensitizers, which generate reactive oxygen species via a photochemical mechanism, leading to cellular necrosis or apoptosis. The present work aims at loading some sensitizers, as porphyrins (P) and phthalocyanines (Pc) into alginate particles. Particles were prepared by dropping alginate into an aqueous solution containing P or Pc and CaCl2, which allows the formation of particles through ionic crosslinking. It was obtained P or Pc loaded alginate beads with an average diameter of about 100 μm. For these systems, this paper analyses the spectroscopic properties, encapsulation into microcapsules, controlled releasing action and their photosensitizer capacity (singlet oxygen generation).