Effect of Cooling Rates on Shape and Crystal Size Distributions of Mefenamic Acid Polymorph in Ethyl Acetate

2nd International Conference on Materials Engineering and Nanotechnology

材料科学;物理学

Abdul Mudalip, S.K.^1 ; Adam, F.^1 ; Parveen, J.^2 ; Abu Bakar, M.R.^3 ; Amran, N.^1 ; Sulaiman, S.Z.^1 ; Che Man, R.^1 ; Mohd Arshad, Z.I.^1 ; Shaarani, S. Md.^1

Faculty of Chemical Engineering and Natural Resources, Universiti Malaysia Pahang, Pahang, Gambang

26300, Malaysia^1

Department of Biotechnology Engineering, Kulliyyah of Engineering, International Islamic University Malaysia, Kuala Lumpur

50728, Malaysia^2

Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Bandar Indera Mahkota, Pahang, Kuantan

25200, Malaysia^3

关键词: Cooling rates;    Crystal size distributions;    Crystallization process;    Ethyl acetates;    Mefenamic acid;    Needle-like;    Polymorphic forms;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/205/1/012025/pdf
DOI  :  10.1088/1757-899X/205/1/012025

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

This study investigate the effect of cooling rates on mefenamic acid crystallisation in ethyl acetate. The cooling rate was varied from 0.2 to 5 °C/min. The in-line conductivity system and turbidity system were employed to detect the onset of the crystallization process. The crystals produced were analysed using optical microscopy and Fourier transform infrared spectroscopy (FTIR). It was found that the crystals produced at different cooling rates were needle-like and exhibit polymorphic form type I. However, the aspect ratio and crystal size distributions were varied with the increased of cooling rate. A high crystals aspect ratio and narrower CSD (100-900 μm) was obtained at cooling rate of 0.5 °C/min. Thus, can be suggested as the most suitable cooling rate for crystallization of mefenamic acid in ethyl acetate.