Effect of Oral Administration of Tungsten Trioxide (WO3) Particles on Hispathological Feature of liver and kidney in Rat

1st Annual Applied Science and Engineering Conference

工业技术;自然科学

Munawaroh, H.S.H.^1 ; Nandiyanto, A.B.D.^1 ; Gumilar, G.G.^1 ; Widi, A.^1 ; Subangkit, M.^2

Departemen Kimia, FPMIPA, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi No. 229, Jawa Barat

40154, Indonesia^1

Fakultas Kedokteran Hewan, Institut Pertanian Bogor, Kampus IPB Darmaga, Jl. Agatis, Jawa Barat, Bogor, Indonesia^2

关键词: Biochemical changes;    Blood urea nitrogens;    Control groups;    Non-toxic compounds;    Oral administration;    Sub- acute toxicities;    Toxicological evaluation;    Tungsten trioxide;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/180/1/012097/pdf
DOI  :  10.1088/1757-899X/180/1/012097

来源: IOP

【 摘 要 】

This study aims to investigate the toxicity and histopathology of tungsten trioxide (WO3) administration on rat's liver and kidney. The LD50of WO3was determined and the sub acute toxicity was evaluated by orally administration of 5000 mg kg-1of WO3to rat for 14 consecutive days. Parameter of blood cells, ALT, creatinine, and BUN were experimentally measured. The toxicological evaluation showed that WO3is a non toxic compound with the LD50higher that 5000 mg kg-1. No biochemical change was observed for creatinine and Blood Urea Nitrogen parameter. In contrast, ALT parameter shows higher value in the experiment than that in the control group. Histopathological changes on rat's liver and kidney were also studied. Small defects in rat's liver and kidney were found, which may interfere the functional of related enzymes.