The interaction of a binary/ternary interactive mixture of hydrophobic-hydrophilic materials on the drug distribution and drug release performance in the tablet formulation

International Conference on Advanced Materials for Better Future 2016

Ainurofiq, A.^1 ; Choiri, S.^1,2

Department of Pharmacy, Sebelas Maret University, Ir. Sutami 36A, Surakarta

57126, Indonesia^1

Faculty of Pharmacy, Gadjah Mada University, Sekip Utara Yogyakarta

55281, Indonesia^2

关键词: Binary and ternary mixtures;    Drug distribution;    Hydrophilic materials;    Hydrophobic Material;    Hydrophobic-hydrophilic;    Magnesium stearate;    Tablet formulations;    Ternary mixtures;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/176/1/012006/pdf
DOI  :  10.1088/1757-899X/176/1/012006

来源: IOP

【 摘 要 】

The aim of this research was to optimize and determine an interaction of a binary/ternary mixture of hydrophobic-hydrophilic materials (H-HM) on the drug distribution, tablet characteristics, and drug release performance. The interactive mixture (IM) between carrier and H-HM was conducted using a carrier, Pruv and Cab-O-Sil as hydrophilic materials, magnesium stearate as a hydrophobic material, and a micronized nifedipine as a drug model. These interactions between binary and ternary mixtures of H-HM were assessed by a simplex centroid design (SCD) approach. The homogeneity of IM between drug and carrier was achieved at more time of mixing time. Unique effects and interactions of H-HM were observed on the drug distribution and drug release. Furthermore, the SCD had successfully determined the optimum design space of IM in the ternary mixture of H-HM.