Development of bioengineering system for stem cell proliferation

4th ModTech International Conference - Modern Technologies in Industrial Engineering

Park, H.S.^1 ; Shah, R.^1 ; Shah, C.^1

Mechanical Engineering Department, University of Ulsan, 93-Daehak-ro, Nam-gu, Ulsan

44610, Korea, Republic of^1

关键词: Biological parameter;    Bioreactor cultures;    Growing conditions;    Healthy environments;    Intensive research;    Mechanical device;    Reciprocating motion;    Tissues engineerings;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/145/7/072010/pdf
DOI  :  10.1088/1757-899X/145/7/072010

来源: IOP

【 摘 要 】

From last decades, intensive research in the field of stem cells proliferation had been promoted due to the unique property of stem cells to self-renew themselves into multiples and has potential to replicate into an organ or tissues and so it's highly demanding though challenging. Bioreactor, a mechanical device, works as a womb for stem cell proliferation by providing nutritious environment for the proper growth of stem cells. Various factors affecting stem cells growth are the bioreactor mechanism, feeding of continuous nutrients, healthy environment, etc., but it always remains a challenge for controlling biological parameters. The present paper unveils the design of mechanical device commonly known as bioreactor in tissues engineering and biotech field, use for proliferation of stem cells and imparts the proper growing condition for stem cells. This high functional bioreactor provides automation mixing of cell culture and stem cells. This design operates in conjunction with mechanism of reciprocating motion. Compare to commercial bioreactors, this proposed design is more convenient, easy to operate and less maintenance is required as bioreactor culture bag is made of polyethylene which is single use purpose. Development of this bioengineering system will be beneficial for better growth and expansion of stem cell.