The silver ions contribution into the cytotoxic activity of silver and silver halides nanoparticles

3rd International Youth Conference on Interdisciplinary Problems of Nanotechnology, Biomedicine and Nanotoxicology

物理学;医药卫生;生态环境科学

Klimov, A.I.^1 ; Zherebin, P.M.^1 ; Gusev, A.A.^2 ; Kudrinskiy, A.A.^1,3 ; Krutyakov, Y.A.^1,3

Department of Chemistry, M.V. Lomonosov Moscow State University, 1-3, Leninskie Gory, Moscow

119991, Russia^1

G.R. Derzhavin Tambov State University, Internatsionalnaya Str., 33, Tambov

392000, Russia^2

National Research Centre kurchatov Institute, Akademika Kurchatova Pl., 1, Moscow

123182, Russia^3

关键词: Biocidal action;    Cell loss;    Cytotoxic activities;    Silver ions;    Silver nitrates;    Sodium citrate;    Sorbitan monooleate;    Yeast cell;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/98/1/012034/pdf
DOI  :  10.1088/1757-899X/98/1/012034

来源: IOP

【 摘 要 】

The biocidal action of silver nanoparticles capped with sodium citrate and silver halides nanoparticles capped with non-ionic surfactant polyoxyethylene(20)sorbitan monooleate (Tween 80®) against yeast cells Saccharomyces cerevisiae was compared to the effect produced by silver nitrate and studied through the measurement of cell loss and kinetics of K+efflux from the cells. The cytotoxicity of the obtained colloids was strongly correlated with silver ion content in the dispersions. The results clearly indicated that silver and silver halides nanoparticles destroyed yeast cells through the intermediate producing of silver ions either by dissolving of salts or by oxidation of silver.