Chitosan-g-lactide copolymers for fabrication of 3D scaffolds for tissue engineering

2015 Global Conference on Polymer and Composite Materials

材料科学;化学

Demina, T.S.^1 ; Zaytseva-Zotova, D.S.^2 ; Timashev, P.S.^3 ; Bagratashvili, V.N.^3 ; Bardakova, K.N.^3 ; Sevrin, Ch^4 ; Svidchenko, E.A.^1 ; Surin, N.M.^1 ; Markvicheva, E.A.^2 ; Grandfils, Ch^4 ; Akopova, T.A.^1

Enikolopov Institute of Synthetic Polymer Materials, Russian Academy of Sciences, Profsoyuznaya Str., 70, Moscow

117393, Russia^1

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Str., 16/10, Moscow

117997, Russia^2

Institute on Laser and Information Technologies, Russian Academy of Sciences, Pionerskaya Str., 2, Moscow (Troitsk)

142190, Russia^3

Interfacultary Research Centre on Biomaterials (CEIB), University of Liège, Chemistry Institute, B6C, Allée du 6 août 11, Liege (Sart-Tilman)

B-4000, Belgium^4

关键词: Amphiphilic property;    Lactide copolymers;    Macroporous hydrogels;    Polymerization degree;    Solid state copolymerization;    Spherical micro particles;    Substitution degree;    Two-photon photopolymerization;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/87/1/012074/pdf
DOI  :  10.1088/1757-899X/87/1/012074

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Chitosan-g-oligo (L, D-lactide) copolymers were synthesized and assessed to fabricate a number of 3D scaffolds using a variety of technologies such as oil/water emulsion evaporation technique, freeze-drying and two-photon photopolymerization. Solid-state copolymerization method allowed us to graft up to 160 wt-% of oligolactide onto chitosan backbone via chitosan amino group acetylation with substitution degree reaching up to 0.41. Grafting of hydrophobic oligolactide side chains with polymerization degree up to 10 results in chitosan amphiphilic properties. The synthesized chitosan-g-lactide copolymers were used to design 3D scaffolds for tissue engineering such as spherical microparticles and macroporous hydrogels.