The preparation of a kind of phenylephrine intermediates

2015 Global Conference on Polymer and Composite Materials

材料科学;化学

Jiang, Pan^1 ; Liu, Feng^1

School of Perfume and Aroma Technology, Shanghai Institute of Technology, 100 Haiquan Rd, Shanghai

201418, China^1

关键词: Acetophenones;    Low costs;    Phenylephrine;    Simple operation;    Target compound;    Two step method;    Waste production;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/87/1/012038/pdf
DOI  :  10.1088/1757-899X/87/1/012038

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

A two-step method to accomplish the synthesis of the important intermediate α-(N-methyl-N-benzylamino) -3-hydroxy acetophenone hydrochloride was discussed, including a brominaion and the following amination. Starting from the commercial available raw material, the target compound could be gained with 62% yield. This procedure involves cheap and easily obtained raw materials, simple operation, low cost, low waste production.