DNA compaction by poly (amido amine) dendrimers of ammonia cored and ethylene diamine cored

Frontiers in Theoretical and Applied Physics/UAE 2017

Qamhieh, K.^1 ; Al-Shawwa, J.^1

Physics Department, College of Science and Technology, Al-quds University, Jerusalem, Israel^1

关键词: Dendrimer generation;    DNA compactions;    Ethylene diamine;    Linear polyelectrolytes;    Persistence length;    Polyamidoamine dendrimers;    Salt concentration;    Theoretical modeling;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/869/1/012055/pdf
DOI  :  10.1088/1742-6596/869/1/012055

来源: IOP

【 摘 要 】

The complexes build-up of DNA and soft particles poly amidoamine (PAMAM) dendrimers of ammonia cored of generations (G1-G6) and ethylenediamine cored of generations (G1-G10) have been studied, using a new theoretical model developed by Qamhieh and coworkers. The model describes the interaction between linear polyelectrolyte (LPE) chain and ion-penetrable spheres. Many factors affecting LPE/dendrimer complex have been investigated such as dendrimer generation, the Bjerrum length, salt concentration, and rigidity of the LPE chain represented by the persistence length. It is found that the wrapping chain length around dendrimer increases by increasing dendrimer's generation, Bjerrum length, and salt concentration, while decreases by increasing the persistence length of the LPE chain. Also we can conclude that the wrapping length of LPE chain around ethylenediamine cored dendrimers is larger than its length around ammonia cored dendrimers.