Pre and post PET-CT impact on oesophageal cancer management: a retrospective analysis.

10th International Seminar on Medical Physics; 1st AMDI International Oncology Symposium

物理学;医药卫生

Azmi, N.A.^1,2 ; Razak, H.R.A.^1 ; Vinjamuri, S.^3

Department of Medical Imaging, Faculty of Health Sciences, Universiti Teknologi MARA (UiTM), Selangor, Puncak Alam Campus, Puncak Alam, Selangor

42300, Malaysia^1

Diagnostic Imaging and Radiotherapy Programme, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur

50300, Malaysia^2

Department of Nuclear Medicine, Royal Liverpool University Hospital, Liverpool

L7 8XP, United Kingdom^3

关键词: Cancer management;    Chi-square tests;    Confidence interval;    Cost effectiveness analysis;    Decision tree modeling;    Demographic profile;    Multiple logistic regression;    Retrospective analysis;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/851/1/012040/pdf
DOI  :  10.1088/1742-6596/851/1/012040

学科分类：卫生学

来源: IOP

【 摘 要 】

Assessment of the retrospective cancer incidence, prevalence and crude survival rates of oesophageal cancer to allow comparison between pre and post PET-CT introduction are part of 4 phase cost effectiveness research. It will provide baseline data for to assess PET or PET-CT cost effective potential for staging. A total of 849 patient's data received from NWCIS databases with various stages of oesophageal cancer between 2001 and 2008. The fundamental activities are retrospective analysis of patient data. In most cases where appropriate, results are presented with 95 percent confidence intervals (CI). Variances between patient groups and variables are assessed using chi-square test. In cases where it deems vital, multiple logistic regression are used to modify for potential confounder such as age and sex. All p-values are two-sided and any value lower than 0.05 were considered to suggest a statistically significant result. Retrospective analysis were categorised into two categories, patients from 2001-2003 considered as pre PET and post PET for 2004-2008. This categorisation allows better comparison of patients' survival trend to be made between both groups. Rates are presented in percentages and being grouped by tumour characteristics and other variables associated with demographic profile, diagnosis, staging and treatment. Results allowed comparison of oesophageal cancer trends between the pre and post PET-CT introduction such as changes in incidence rate or changes in survival. These data were used to normalise the decision tree model so that cost-effectiveness analysis can be performed across the whole population.