Effects of pre- and post-electrospinning plasma treatments on electrospun PCL nanofibers to improve cell interactions

7th Young Researcher Meeting

Asadian, M.^1 ; Grande, S.^1 ; Morent, R.^1 ; Nikiforov, A.^1 ; Declercq, H.^2 ; De Geyter, N.^1

Faculty of Engineering and Architecture, Department of Applied Physics, Research Unit Plasma Technology (RUPT), Ghent University, Sint-Pietersnieuwstraat 41 B4, Ghent

9000, Belgium^1

Faculty of Medicine and Health Science, Department of Basic Medical Sciences, Tissue Engineering and Biomaterials Group, Ghent University, De Pintelaan 185 6B3, Ghent

9000, Belgium^2

关键词: Cell interaction;    Cellular interaction;    Dielectric barrier discharge plasmas;    Electrospun mats;    Liquid plasmas;    PCL nanofibers;    Plasma treatment;    Surface hydrophilicity;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/841/1/012018/pdf
DOI  :  10.1088/1742-6596/841/1/012018

来源: IOP

【 摘 要 】

In this study, liquid plasma treatment was used to improve the morphology of Poly-J-CaproLactone (PCL) NanoFibers (NFs), followed by performing a Dielectric Barrier Discharge (DBD) plasma surface modification to enhance the hydrophilicity of electrospun mats generated from plasma-modified PCL solutions. Cell interaction studies performed after 1 day and 7 days clearly revealed the highly increased cellular interactions on the double plasma-treated nanofibers compared to the pristine ones due to the combination of (1) a better NF morphology and (2) an increased surface hydrophilicity.