In vivo evaluation of the potential neurotoxicity of aerosols released from mechanical stress of nano-TiO2 additived paints in mice chronically exposed by inhalation

5th Nanosafe International Conference on Health and Safety issues related to nanomaterials for a socially responsible approach

物理学;医药卫生;材料科学

Manixay, S.^1 ; Delaby, S.^2 ; Gaie-Levrel, F.^3 ; Wiart, M.^4 ; Motzkus, C.^5 ; Bencsik, A.^1

Université de Lyon 1, ANSES, Unité Maladies Neurodégénératives, Lyon, France^1

Centre Scientifique et Technique du Bâtiment (CSTB), Saint-Martin d'Heres, France^2

Laboratoire National de Métrologie et d'Essais (LNE), Paris, France^3

Univ-Lyon, CarMeN Laboratory, Inserm U1060, INRA U1397, Université Claude Bernard Lyon 1, INSA Lyon, Charles Mérieux Medical School, Oullins, France^4

Centre Scientifique et Technique du Bâtiment (CSTB), Marne-la-Vallée, France French Agency for Food, Environmental and Occupational Health Safety (ANSES), France^5

关键词: Engineered nanomaterials;    Experimental set up;    Particulate Matter;    Photocatalytic activities;    Physical chemical property;    Self-cleaning properties;    TiO2 nano-particles;    Titanium dioxides (TiO2);   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/838/1/012025/pdf
DOI  :  10.1088/1742-6596/838/1/012025

来源: IOP

【 摘 要 】

Engineered Nanomaterials (ENM) provide technical and specific benefits due to their physical-chemical properties at the nanometer scale. For instance, many ENM are used to improve products in the building industry. Nanoscaled titanium dioxide (TiO2) is one of the most used ENM in this industry. Incorporated in different matrix, cement, glass, paints... TiO2nanoparticles (NPs) provide the final product with anti-UV, air purification and self-cleaning properties, thanks to their photocatalytic activity. However, ageing processes of such products, as photocatalytic paints, during a mechanical stress have been shown to release TiO2NPs from this matrix associated with sanding dust. Thus, workers who sand painted walls could be exposed to TiO2NPs through inhalation. As inhalation may lead to a translocation of particulate matter to the brain via olfactory or trigeminal nerves, there is an urgent need for evaluating a potential neurotoxicity. In order to provide new knowledge on this topic, we developed a dedicated experimental set-up using a rodent model exposed via inhalation. The aerosol released from a mechanical stress of photocatalytic paints containing TiO2NPs was characterized and coupled to an exposition chamber containing group of mice free to move and chronically exposed (2 hours per day for 5 days a week during 8 weeks).