Synthetic techniques of radiopharmaceuticals production labeled with C-11 for PET in cardiology

1st International Symposium 'Physics, Engineering and Technologies for Bio-Medicine'

医药卫生;物理学;工业技术

Dyubkov, V.S.^1,2 ; Ekaeva, I.V.^2 ; Katunina, T.A.^2 ; Rumyantsev, A.S.^2 ; Silchenkov, A.V.^2 ; Tuflina, T.V.^2

Electrophysical Facilities Department, National Research Nuclear University MEPhI, Kashirskoe shosse 31, Moscow

115409, Russia^1

Bakulev Scientific Centre for Cardiovascular Surgery, Rublyovskoe shosse 135, Moscow

121552, Russia^2

关键词: Heart muscles;    Non-invasive diagnostics;    PET Scan;    Physiological process;    Positron emission tomography (PET);    Synthesis techniques;    Synthetic analogues;    Synthetic techniques;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/784/1/012020/pdf
DOI  :  10.1088/1742-6596/784/1/012020

来源: IOP

【 摘 要 】

Positron emission tomography (PET) and PET-Computerised Tomography (CT) are unique, non-invasive diagnostic techniques, in which the local, temporal and quantitative distributions of radioactive labelled substances are measured to investigate physiological processes. It is well known that PET centre of Bakulev Scientific Centre for Cardiovascular Surgery is the oldest one in Moscow. During more than fifteen years a large number of patients have received PET scans. Due to main stream of Scientific Centre, emphasis is placed on examining the heart functioning. For the diagnosis innervation of the heart muscle a number of radiopharmaceuticals are used, including PET radiopharmaceuticals such as11C-CGP 12177,11C-meta-hydroxyephedrine as well as its synthetic analogues labelled with other PET radionuclides (18F,68Ga).11C-meta-hydroxyephedrine is one of the most perspective radiopharmaceutical for an investigation of cardiac receptors function due to required materials availability for a radio synthesis in Russia. The main advantage of proposed11C-meta-hydroxyephedrine synthesis technique is the use of a catalyst which allows one decrease reaction time from 5 minutes to 30 seconds. Obtained results allow one decrease reaction time of methylation and increase radiochemical and technological yields.