Synthesis of polystyrene core/SiO2 shell composite particles and fabrication of SiO2 capsules out of them

1st International Symposium 'Physics, Engineering and Technologies for Bio-Medicine'

医药卫生;物理学;工业技术

Terekhin, V.^1,2

Laboratory of Nano-Bioengineering, National Research Nuclear University, MEPhI (Moscow Engineering Physics Institute), Moscow, Russia^1

Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, bld 4, 31 Leninsky prospekt, Moscow

119071, Russia^2

关键词: Cationic initiators;    Composite particles;    High temperature;    Mean pore diameters;    Model experiments;    Polystyrene core;    Polystyrene particle;    Visible spectral regions;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/784/1/012006/pdf
DOI  :  10.1088/1742-6596/784/1/012006

来源: IOP

【 摘 要 】

Systemic studies on the dependence of the morphology of polystyrene core/SiO2shell composite particles on the conditions of their fabrication have been performed. Spherical polystyrene particles synthesized in the presence of a cationic initiator of polymerization were used as cores. SiO2shells were formed by modified Stober's method. Exposure of the synthesized composite particles to high temperatures has been shown to cause destruction of their polystyrene core, thereby allowing the formation of mesoporous SiO2capsules with a mean pore diameter of ∼3 nm and specific surface area of ∼270 m2/g. Model experiments on loading the SiO2capsules with amoxicillin have been carried out. Spectrophotometry in the UV and visible spectral regions has been used to estimate the kinetics of amoxicillin release from the SiO2capsules.