Advances in biological dosimetry

Micro-Mini & Nano-Dosimetry & Innovative Technologies in Radiation Therapy

Ivashkevich, A.^1,2 ; Ohnesorg, T.^3 ; Sparbier, C.E.^1 ; Elsaleh, H.^1,4

Radiation Oncology, Canberra Hospital, Garran

ACT

2605, Australia^1

Australian National University, Canberra

ACT

2600, Australia^2

Molecular Development, Murdoch Children's Research Institute, Melbourne

VIC

3052, Australia^3

College of Medicine Biology and Environment, Australian National University, Canberra

ACT

2600, Australia^4

关键词: Biodosimetry;    Biological dosimetry;    Ease-of-use;    Gene expression signatures;    High-throughput analysis;    Radiation Exposure;    Reliable measurement;    Sample preparation;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/777/1/012012/pdf
DOI  :  10.1088/1742-6596/777/1/012012

来源: IOP

【 摘 要 】

Rapid retrospective biodosimetry methods are essential for the fast triage of persons occupationally or accidentally exposed to ionizing radiation. Identification and detection of a radiation specific molecular 'footprint' should provide a sensitive and reliable measurement of radiation exposure. Here we discuss conventional (cytogenetic) methods of detection and assessment of radiation exposure in comparison to emerging approaches such as gene expression signatures and DNA damage markers. Furthermore, we provide an overview of technical and logistic details such as type of sample required, time for sample preparation and analysis, ease of use and potential for a high throughput analysis.