Synchrotron activation radiotherapy: Effects of dose-rate and energy spectra to tantalum oxide nanoparticles selective tumour cell radiosentization enhancement

Micro-Mini & Nano-Dosimetry & Innovative Technologies in Radiation Therapy

Engels, E.^1,2 ; Lerch, M.^1,2 ; Tehei, M.^1,3 ; Konstantinov, K.^2,4 ; Guatelli, S.^1 ; Rosenfeld, A.^1,2 ; Corde, S.^1,2,5

Centre for Medical Radiation Physics, University of Wollongong (UOW), Australia^1

Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, Australia^2

Centre for Medical and Molecular Bioscience (CMMB), University of Wollongong, Australia^3

Institute for Superconducting and Electronic Materials (ISEM), University of Wollongong, Australia^4

Radiation Oncology Department, Prince of Wales Hospital, Randwick

NSW, Australia^5

关键词: Energy dependence;    Kiloelectronvolt;    Madin-Darby canine kidneys;    Nano-structured;    Oxide nanoparticles;    Radiation field;    Synchrotron beams;    Tantalum pentoxide;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/777/1/012011/pdf
DOI  :  10.1088/1742-6596/777/1/012011

来源: IOP

【 摘 要 】

Synchrotron radiation is unique in its ability to deliver dose at high dose rates using kiloelectronvolt photons. We are investigating the use of Tantalum pentoxide (Ta2O5) nano-structured particles (NSPs) that are to date unexplored in synchrotron radiation fields as they have high atomic number (Z=73) are biocompatible and are therefore potential radio sensitizers. We exposed cell culture flasks containing 9L gliosarcoma tumour cells or Madin-Darby Canine Kidney (MDCK) non-tumour cells to the NSPs and treated the cells using a broad synchrotron beam (140 keV median energy; average dose rate of 50 Gy/s) at the Australian Synchrotron. We compare the results with those from similar cells treated using a conventional 150 kVporthovoltage field (dose rate of 0.0127 Gy/s). The results reveal that the high dose-rate synchrotron irradiation is more effective at killing the 9L cells relative to the MDCK cells than the orthovoltage irradiation. On the other hand, the NSPs are more effective at radiosensitizing the 9L cells compared to the MDCK cells in the orthovoltage radiation field, which is due to the NSP energy dependence in the kilovoltage energy range. Both the dose rate and energy spectrum need to be considered in future studies with synchrotron activation radiotherapy (SART).