A Two-Layer Mathematical Modelling of Drug Delivery to Biological Tissues

27th IUPAP Conference on Computational Physics

物理学;计算机科学

Chakravarty, Koyel^1 ; Dalal, D.C.^1

Department of Mathematics, Indian Institute of Technology Guwahati, Guwahati

Assam, India^1

关键词: Biological tissues;    Drug delivery devices;    Local drug delivery;    Physicochemical property;    Reversible dissociation;    Spatio-temporal models;    System of partial differential equations;    Therapeutic drugs;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/759/1/012023/pdf
DOI  :  10.1088/1742-6596/759/1/012023

学科分类：计算机科学（综合）

来源: IOP

【 摘 要 】

Local drug delivery has received much recognition in recent years, yet it is still unpredictable how drug efficacy depends on physicochemical properties and delivery kinetics. The purpose of the current study is to provide a useful mathematical model for drug release from a drug delivery device and consecutive drug transport in biological tissue, thereby aiding the development of new therapeutic drug by a systemic approach. In order to study the complete process, a two-layer spatio-temporal model depicting drug transport between the coupled media is presented. Drug release is described by considering solubilisation dynamics of drug particle, diffusion of the solubilised drug through porous matrix and also some other processes like reversible dissociation / recrystallization, drug particle-receptor binding and internalization phenomena. The model has led to a system of partial differential equations describing the important properties of drug kinetics. This model contributes towards the perception of the roles played by diffusion, mass-transfer, particle binding and internalization parameters.