Validation of the method of quantitative phase analysis by X-ray diffraction in API: case of Tibolone

8th Brazilian Congress on Metrology

Silva, R.P.^1,2 ; Ambrósio, M.F.S.^1,5 ; Epprecht, E.K.^2 ; Avillez, R.R.^3 ; Achete, C.A.^4 ; Kuznetsov, A.^4 ; Visentin, L.C.^5

Universidade Federal Do Rio de Janeiro, Campus de Xerém, Duque de Caxias

RJ

25245-390, Brazil^1

Pontifícia Universidade Católica Do Rio de Janeiro, Centro Técnico-Científico, Departamento de Engenharia Industrial, Rio de Janeiro

RJ

22451-900, Brazil^2

Pontifícia Universidade Católica Do Rio de Janeiro, Centro Técnico-Científico, Departamento de Engenharia Química e de Materiais, Rio de Janeiro

RJ

22451-900, Brazil^3

INMETRO, Instituto Nacional de Metrologia, Qualidade e Tecnologia, Duque de Caxias

RJ

25250-020, Brazil^4

NanoBusiness Informação e Inovação Ltda, Duque de Caxias

RJ

25250-020, Brazil^5

关键词: Microstructural models;    Powder diffraction;    Quantitative phase analysis;    X ray data;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/733/1/012030/pdf
DOI  :  10.1088/1742-6596/733/1/012030

来源: IOP

【 摘 要 】

In this study, different structural and microstructural models applied to X-ray analysis of powder diffraction data of polymorphic mixtures of known concentrations of Tibolone were investigated. The X-ray data obtained in different diffraction instruments were analysed via Rietveld method using the same analytical models. The results of quantitative phase analysis show that regardless of the instrument used, the values of the calculated concentrations follow the same systematics with respect to the final errors. The strategy to select a specific analytical model that leads to lower measurement errors is here presented.