Characterization of x-rays pulses from a hundred joules plasma focus to study its effects on cancer cells.

19th Chilean Physics Symposium 2014

Jain, J.^1,2,3 ; Moreno, J.^1,2 ; Avaria, G.^1,2 ; Pavez, C.^1,2 ; Bora, B.^1,2 ; Inestrosa Izurieta, M.J.^1,2 ; Diez, D.^4 ; Alvarez, O.^4 ; Tapia, J.^4 ; Marcelain, K.^4 ; Armisen, R.^4 ; Soto, L.^1,2

Comisión Chilena de Energía Nuclear, Casilla Santiago

188-D, Chile^1

Center for Research and Applications in Plasma Physics and Pulsed Power, P4, Chile^2

Universidad de Talca, Chile^3

Instituto de Ciencias Biomedicas and Centro de Investigation y Tratamiento Del Cancer, Facultad de Medicina, Universidad de Chile, Chile^4

关键词: Breast cancer cells;    Discharge chamber;    Plasma focus devices;    Plastic scintillator;    Pulsed X-rays;    Radial direction;    Single shots;    Temporal durations;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/720/1/012043/pdf
DOI  :  10.1088/1742-6596/720/1/012043

来源: IOP

【 摘 要 】

With the purpose to study the effects of pulsed x-rays radiation on cancer cells, the total doses of x-ray pulses and the temporal duration of the pulse has been characterized in a hundred joules plasma focus device (PF-400J, 130 kA achieved in 300ns, 30 kV, 880 nF, 38 nH). TLD dosimeters were located outside of the discharge chamber, at 96 mm from the anode top. In addition, two photomultipliers with plastic scintillator were located in axial and radial directions. From the statistical analysis of the TLD and photomultiplier signals, was possible to estimate that a single shot has a total dose of the order of 30±15 μSv with a duration of the order of 12±3.6 ns at FWHM. Preliminary experiments using MCF7, a breast cancer cell line, were performed. Cells were irradiated at 96 mm from the anode top with 300 cumulative x-ray shots and cell proliferation was evaluated at 24, 48 and 72 hours later.