From 3D Bioprinters to a fully integrated Organ Biofabrication Line

20th Argentinean Bioengineering Society Congress

物理学;生物科学

Passamai, V.E.^1 ; Dernowsek, J.A.^1 ; Nogueira, J.^1 ; Lara, V.^1 ; Vilalba, F.^1 ; Mironov, V.A.^1 ; Rezende, R.A.^1 ; Da Silva, J.V.^1

Divisao de Tecnologias Tridimensionais (DT3D), Centro de Tecnologia da Informacao Renato Archer (CTI), Rodovia Dom Pedro I (SP-65) km 143, Amarais -Campinas, SP 6, Brazil^1

关键词: Biofabrication;    Cell aggregates;    Complex organs;    Disease research;    Equipment development;    Fully integrated;    Medical science;    Tissue constructs;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/705/1/012010/pdf
DOI  :  10.1088/1742-6596/705/1/012010

学科分类：生物科学（综合）

来源: IOP

【 摘 要 】

About 30 years ago, the 3D printing technique appeared. From that time on, engineers in medical science field started to look at 3D printing as a partner. Firstly, biocompatible and biodegradable 3D structures for cell seeding called "scaffolds" were fabricated for in vitro and in vivo animal trials. The advances proved to be of great importance, but, the use of scaffolds faces some limitations, such as low homogeneity and low density of cell aggregates. In the last decade, 3D bioprinting technology emerged as a promising approach to overcome these limitations and as one potential solution to the challenge of organ fabrication, to obtain very similar 3D human tissues, not only for transplantation, but also for drug discovery, disease research and to decrease the usage of animals in laboratory experimentation. 3D bioprinting allowed the fabrication of 3D alive structures with higher and controllable cell density and homogeneity. Other advantage of biofabrication is that the tissue constructs are solid scaffold-free. This paper presents the 3D bioprinting technology; equipment development, stages and components of a complex Organ Bioprinting Line (OBL) and the importance of developing a Virtual OBL.