Study on the effect of nanoparticle bimetallic coreshell Au-Ag for sensitivity enhancement of biosensor based on surface plasmon resonance

13th South-East Asian Congress of Medical Physics 2015

物理学;医药卫生

Widayanti^1,2 ; Abraha, K.^2

Department of Physics, Faculty of Sciences and Technology, UIN Sunan Kalijaga, Yogyakarta, Indonesia^1

Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta, Indonesia^2

关键词: Attenuated total reflection spectrums;    Bimetallic core-shell nanoparticles;    Bimetallic nanoparticles;    Biomolecular interactions;    Effective medium theories;    Kretschmann configuration;    Sensitivity enhancements;    Surface plasmon resonance spectroscopy;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/694/1/012075/pdf
DOI  :  10.1088/1742-6596/694/1/012075

学科分类：卫生学

来源: IOP

【 摘 要 】

Bimetallic Au-Ag core-shell, a type of composite spherical nanoparticle consisting of a spherical Au core covered by Ag shell, have been used as active material for biomolecular analyte detection based on surface plasmon resonance (SPR) spectroscopy. SPR technology evolved into a key technology for characterization of biomolecular interaction. In this paper, we want to show the influence of nanoparticle bimettalic Au-Ag coreshell for optic respon of LSPR biosensor through attenuated total reflection (ATR) spectrum. The method consist of several steps begin from make a model LSPR system with Kretschmann configuration, dielectric function determination of composite bimetallic coreshell nanoparticle using effective medium theory approximation and the last is reflectivity calculation for size variation of core and shell bimetallic nanoparticle. Our result show that, by varying the radius of core and shell thickness, the peak of the reflectivity (ATR spectrum) shifted to the different angle of incident light and the addition of coreshell in SPR biosensor leads to enhancement the sensitivity.