Preliminary experience on the implementation of computed tomography (CT)-based image guided brachytherapy (IGBT) of cervical cancer using high-dose-rate (HDR) Cobalt-60 source in University of Malaya Medical Centre (UMMC)

13th South-East Asian Congress of Medical Physics 2015

物理学;医药卫生

Jamalludin, Z.^1,2 ; Min, U.N.^1 ; Ishak, W.Z. Wan^1 ; Malik, R. Abdul^1

Clinical Oncology Unit, Faculty of Medicine, University of Malaya, Malaysia^1

Medical Physics Unit, University Malaya Medical Center, Malaysia^2

关键词: Brachytherapy;    Cervical cancers;    External beam radiotherapy;    High dose rate;    Image-guided;    Magnetic Resonance Imaging (MRI);    Point-based;    Treatment planning systems;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/694/1/012016/pdf
DOI  :  10.1088/1742-6596/694/1/012016

学科分类：卫生学

来源: IOP

【 摘 要 】

This study presents our preliminary work of the computed tomography (CT) image guided brachytherapy (IGBT) implementation on cervical cancer patients. We developed a protocol in which patients undergo two Magnetic Resonance Imaging (MRI) examinations; a) prior to external beam radiotherapy (EBRT) and b) prior to intra-cavitary brachytherapy for tumour identification and delineation during IGBT planning and dosimetry. For each fraction, patients were simulated using CT simulator and images were transferred to the treatment planning system. The HR-CTV, IR-CTV, bladder and rectum were delineated on CT-based contouring for cervical cancer. Plans were optimised to achieve HR-CTV and IR-CTV dose (D90) of total EQD280Gy and 60Gy respectively, while limiting the minimum dose to the most irradiated 2cm3volume (D2cc) of bladder and rectum to total EQD290Gy and 75Gy respectively. Data from seven insertions were analysed by comparing the volume-based with traditional point- based doses. Based on our data, there were differences between volume and point doses of HR- CTV, bladder and rectum organs. As the number of patients having the CT-based IGBT increases from day to day in our centre, it is expected that the treatment and dosimetry accuracy will be improved with the implementation.