RTtxGap: An android radiobiological tool for compensation of radiotherapy treatment interruption

13th South-East Asian Congress of Medical Physics 2015

物理学;医药卫生

Yusoff, A.L.^1,2 ; Mohamad, M.^1,2 ; Abdullah, R.^3 ; Bhavaraju, V.M.K.^1,2 ; Idris, N.R. Nik^1,2

Department of Nuclear Medicine, Radiotherapy and Oncology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan

16150, Malaysia^1

Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kubang Kerian, Kelantan

16150, Malaysia^2

School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan

16150, Malaysia^3

关键词: Android applications;    Biological effective dose;    Dose prescription;    Linear-quadratic models;    Machine breakdown;    Radiation reactions;    Radiotherapy treatment;    Treatment interruption;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/694/1/012012/pdf
DOI  :  10.1088/1742-6596/694/1/012012

学科分类：卫生学

来源: IOP

【 摘 要 】

Treatment interruption is not uncommon in radiotherapy. Common reasons for treatment interruption include machine breakdown, holidays and patient severe radiation reactions. Here RTtxGap, an Android application to assist calculations of compensation for treatment gap, is reported. It uses linear quadratic (LQ) model to calculate the biological effective dose (BED) that is used to solve for treatment gap compensations. Solutions are calculated using BED equation, with consideration for tissue proliferation. The accuracy of results has been verified using LQL Equiv software to be accurate within 1%. Five treatment interruption examples were used to illustrate the capability of the software to calculate the treatment compensation schedules. Solving these examples also illustrates the general consensus regarding compensating for unscheduled treatment interruptions, which ultimately involves balancing the BEDs of tumour and organ at risk. In addition to compensation for treatment gap, RTtxGap can also be used to calculate equivalent total dose in 2-Gy fraction (EQD2), to modify treatment schedule and to calculate alternative dose prescriptions having the same isoeffect.