Mathematical modeling of the magnetization transfer effect in tissues

2nd International Conference and Young Scientist School "Magnetic resonance imaging in biomedical research"

Yarnykh, V.^1,2

Vascular Imaging Lab, Department of Radiology, University of Washington, Seattle

WA, United States^1

Neurobiology Lab, Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russia^2

关键词: Biological objects;    Biophysical mechanism;    Experimental methods;    Magnetic energies;    Magnetic Resonance Imaging (MRI);    Magnetization transfer;    Preparation technique;    Quantitative tissue characterization;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/677/1/012001/pdf
DOI  :  10.1088/1742-6596/677/1/012001

来源: IOP

【 摘 要 】

The term magnetization transfer (MT) describes a group of molecular processes causing incoherent exchange of magnetic energy between water and macromolecules in biological objects. Magnetic resonance imaging (MRI) can be sensitized to the MT effect using various magnetization preparation techniques. Since its introduction in early 90s, MT MRI has been used in various applications as a tool for quantitative or semi-quantitative tissue characterization and modification of tissue contrast. This review article provides an overview of biophysical mechanisms of MT in tissues, in-depth mathematical consideration of the widely used two-pool model of MT, and a summary of experimental methods used to study MT phenomena.