Combination of laser correlation and dielectric spectroscopy in albumin investigations

2nd International School and Conference Saint-Petersburg OPEN on Optoelectronics, Photonics, Engineering and Nanostructures

Nepomnyashchaya, E.^1 ; Cheremiskina, A.^1 ; Velichko, E.^1,2 ; Aksenov, E.^1 ; Bogomaz, T.^1

Saint Petersburg State Polytechnic University, Saint Petersburg, Russia^1

Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, St. Petersburg, Russia^2

关键词: Aggregation dynamics;    Bio-molecular;    Combination of lasers;    Dielectric dissipation factors;    Electrophysical properties;    Maximum frequency;    Molecular size;    Water solutions;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/643/1/012018/pdf
DOI  :  10.1088/1742-6596/643/1/012018

来源: IOP

【 摘 要 】

Joint use of laser correlation and dielectric spectroscopies for studies of biomolecular properties of albumin in water solution is considered. The conditions and parameters of the experiments are discussed. Similar behaviours of albumin molecular sizes and maximum frequency of peak of dielectric dissipation factor with increasing acidity were revealed. Using the suggested approach, biomolecular aggregation dynamics and changes in electrophysical properties on transition from one molecular structure to another may be investigated.