X-ray dual energy spectral parameter optimization for bone Calcium/Phosphorus mass ratio estimation

International Conference on Bio-Medical Instrumentation and related Engineering and Physical Sciences

物理学;医药卫生

Sotiropoulou, P.I.^1 ; Fountos, G.P.^2 ; Martini, N.D.^1 ; Koukou, V.N.^1 ; Michail, C.M.^2 ; Valais, I.G.^2 ; Kandarakis, I.S.^2 ; Nikiforidis, G.C.^1

Department of Medical Physics, Faculty of Medicine, University of Patras, Patras

265 00, Greece^1

Radiation Physics, Materials Technology and Biomedical Imaging Laboratory, Department of Biomedical Engineering, Technological Educational Institute of Athens, Egaleo, Athens

122 10, Greece^2

关键词: Calibration points;    Coefficient of variation;    Energy discriminating;    Mass attenuation coefficients;    Photon counting;    Simulation studies;    Standard deviation;    X-ray dual energy;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/637/1/012025/pdf
DOI  :  10.1088/1742-6596/637/1/012025

学科分类：卫生学

来源: IOP

【 摘 要 】

Calcium (Ca) and Phosphorus (P) bone mass ratio has been identified as an important, yet underutilized, risk factor in osteoporosis diagnosis. The purpose of this simulation study is to investigate the use of effective or mean mass attenuation coefficient in Ca/P mass ratio estimation with the use of a dual-energy method. The investigation was based on the minimization of the accuracy of Ca/P ratio, with respect to the Coefficient of Variation of the ratio. Different set-ups were examined, based on the K-edge filtering technique and single X-ray exposure. The modified X-ray output was attenuated by various Ca/P mass ratios resulting in nine calibration points, while keeping constant the total bone thickness. The simulated data were obtained considering a photon counting energy discriminating detector. The standard deviation of the residuals was used to compare and evaluate the accuracy between the different dual energy set-ups. The optimum mass attenuation coefficient for the Ca/P mass ratio estimation was the effective coefficient in all the examined set-ups. The variation of the residuals between the different set-ups was not significant.