Modelling of poro-visco-elastic biological systems

4th International Conference on Mathematical Modeling in Physical Sciences

物理学;数学

Bilotsky, Y.^1 ; Gasik, M.^1

Department of Material Science and Engineering, Aalto University Foundation School of Chemical Technology, P.O. Box 16200, Aalto

FIN-00076, Finland^1

关键词: Applied forces;    In-vitro;    Non-linear model;    Nonlinear relations;    Static and dynamic loading;    Time and frequencies;    Visco-elastic;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/633/1/012134/pdf
DOI  :  10.1088/1742-6596/633/1/012134

来源: IOP

【 摘 要 】

The research of mechanical properties of poro-visco-elastic biomaterials is an important task, especially for tailoring the best conditions for in-growth and healing of implants. In this work we analysed the behaviour of biomaterials under different static and dynamic loading regimes, in «dry» and «wet» conditions. Retrieved data revealed nonlinear relations between applied force and resulting deformation, with time and frequency dependence. These features were described by a nonlinear model, which reasonably fits mentioned peculiarities. The simplified model was validated with numerical simulations using COMSOL software. Upon validation it allows incorporation of the experimental data obtained by biomechanical spectroscopy towards prediction of biomaterials behaviour in «in vitro» conditions, with the purpose to extrapolate to clinically-relevant environment.