Biological systems: from water radiolysis to carbon ion radiotherapy

CIRIL, 30 years of interdisciplinary research at GANIL

Beuve, Michael^1 ; Moreau, Jean-Michel^2 ; Rodriguez, Claire^3 ; Testa, Etienne^1

IPNL, UMR 5822, CNRS/IN2P3, 4 rue E. Fermi, Villeurbanne Cedex

69622, France^1

LIRIS, Université de Lyon, Université Lyon 1, France^2

LRCM, Université de Lyon, Université Lyon 1, France^3

关键词: Applied research;    Biological properties;    Carbon ion radiotherapy;    Dose deposition;    Efficient treatment;    Hadron therapy;    Localized tumors;    Water radiolysis;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/629/1/012004/pdf
DOI  :  10.1088/1742-6596/629/1/012004

来源: IOP

【 摘 要 】

Hadron therapy is an innovative cancer treatment method based on the acceleration of light ions at high energy. In addition to their interesting profile of dose deposition, which ensures accurate targeting of localized tumors, carbon ions offer biological properties that lead to an efficient treatment for radio- and chemo-resistant tumors and to provide a boost for tumors in hypoxia. This paper is a short review of the progress in theoretical, experimental, fundamental and applied research, aiming at understanding the origin of the biological benefits of light ions better. As a limit of such a vast and multidisciplinary domain, this review adopts the point of view of the physicists, leaning on results obtained in connection with CIMAP's IRRABAT platform.