Organ weight changes in mice after long-term inhalation exposure to manganese oxides nanoparticles

4th International Conference on Safe Production and Use of Nanomaterials

Zeman, T.^1 ; Buchtová, M.^2 ; Doekal, B.^3 ; Míek, I.^2 ; Navrátil, J.^1 ; Mikuka, P.^3 ; Šerý, O.^2 ; Veea, Z.^3

Department of Population Protection, University of Defence, Kounicova 65, Brno

662 10, Czech Republic^1

Institute of Animal Physiology and Genetics, V.v.i., Academy of Sciences of the Czech Republic, Veveí 97, Brno

602 00, Czech Republic^2

Institute of Analytical Chemistry, V.v.i., Academy of Sciences of the Czech Republic, Veveí 97, Brno

602 00, Czech Republic^3

关键词: Acetylacetonates;    Experimental groups;    Flow tube reactor;    Inhalation exposure;    Inhaled particles;    Internal organs;    Laboratory animals;    Metal organic precursors;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/617/1/012018/pdf
DOI  :  10.1088/1742-6596/617/1/012018

来源: IOP

【 摘 要 】

Recently, it has been proven that manganese from inhaled particles of manganese compounds can accumulate in the internal organs of laboratory animals. Nevertheless, there were only a few researches dealing with changes in body morphology induced by inhalation of these particles, even though results of some studies indicate existence of such changes. The aim of our research was to assess the effect of inhaled manganese oxides nanoparticles on weight of internal organs. For this purpose a long-term inhalation experiment on laboratory mice was performed, during which the mice were exposed to MnO.Mn2O3nanoparticles in concentration 2 106particles/cm3for 17 weeks, 24 hours a day, 7 days a week. Manganese oxides nanoparticles were synthesized continuously via aerosol route in a hot wall tube flow reactor using thermal decomposition of metal organic precursor manganese(II)acetylacetonate in the flow tube reactor at temperature 750°C in the presence of 30 vol% of oxygen. It was proven that inhaled nanoparticles can influence the weight of internal organs of mice. Moreover, it was discovered that the resulting change in weight of selected organs is disproportional. The mice from the experimental group had statistically significantly lighter kidneys, liver and spleen and heavier pancreas compared to the mice from the control group.