The influence of selected excipients on the rheological behaviour of chitosan based ocular pharmaceutical systems

1st International Conference on Rheology and Modeling of Materials

物理学;材料科学

Budai, L.^1 ; Szabadi, E.^1 ; Hajdú, M.^1 ; Budai, M.^1 ; Klebovich, I.^1 ; Antal, I.^1

Semmelweis University, Department of Pharmaceutics, Högyes E. u. 7, Budapest

H-1092, Hungary^1

关键词: Carbohydrate polymers;    Concentration ranges;    Linear viscoelastic regions;    Oscillatory frequency;    Pharmaceutical systems;    Rheological behaviour;    Rheological measurements;    Rheological property;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/602/1/012041/pdf
DOI  :  10.1088/1742-6596/602/1/012041

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Aims: Chitosan, a modified natural carbohydrate polymer, has received great attention in diverse scientific fields including pharmaceutical and biomedical research areas. Besides its low toxicity, mucoadhesiveness and biodegradability its special favourable rheological feature makes it a unique gelling agent for the design of ocular systems. Chitosan based (2.0 w/v %) ocular systems containing selected excipients were formulated in order to investigate the rheological influence of applied auxiliary materials. Rotational and oscillatory rheological properties of propylene glycol (1.0-20.0 w/v %), glycerin (1.0-5.0 w/v %) and castor oil (1.0-5.0 w/v %) containing chitosan gels were evaluated. The rheological behaviour of formulated ocular gels were compared before and after steam sterilization. Methods: Rotational and oscillatory rheological measurements were carried out with Kinexus Pro Rheometer. Comparison of flow curves and oscillatory frequency sweep measurements in the linear viscoelastic region made possible the evaluation of rheological effect of selected excipients. Results: In the applied concentration range the effect of propylene glycol among the selected excipients presents the most significant impact on rheology of chitosan formulations. Steam sterilization results in reduced viscosity in most of chitosan gels. However, the presence of polyols appears to prevent the degradation of chitosan after steam sterilization.