Feasibility of PET/CT 3-D dosimetry for proton-activated PRESAGE? dosimeters

8th International Conference on 3D Radiation Dosimetry

Carroll, M.^1,2 ; Ibbott, G.^1 ; Adamovics, J.^3,4

Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston

TX

77030, United States^1

University of Texas at Houston, Graduate School of Biomedical Sciences, Houston

TX

77030, United States^2

Rider University, Lawerenceville

NJ, United States^3

Heuris Pharma, LLC, 412 Sunset Rd., Skillman

NJ

08558, United States^4

关键词: Central axis;    Cross beams;    Dose measurement;    Dose profile;    Feasibility studies;    Material compositions;    Positron emission;    Spatial comparison;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/573/1/012071/pdf
DOI  :  10.1088/1742-6596/573/1/012071

来源: IOP

【 摘 要 】

A feasibility study is considered using PRESAGE® dosimeters as a direct dosimetry comparison tool to correlate proton activation to dose in a clinical beam. Proton activation measured by PET/CT has been studied as a future tool method for in vivo dosimetry. PRESAGE® is a 3D offline dosimeter that has a material composition giving it a longer activation decay time than similar dosimeters allowing easier measurements. In this study, the PRESAGE® positron emissions were measured by PET and directly compared to dose measurements made by optical-CT to make spatial comparisons of dose and proton activation. Profiles along the central axis of the beam found a shift in the distal-80% resulting in the proton activation profile being 1 cm shallower than the dose profile. Cross beam profiles demonstrated little discrepancy between long (3 hour) and short (30 minute) PET scan times.