Opportunities for improving the performance of LCV micelle gel dosimeters: II. Recipe optimization

8th International Conference on 3D Radiation Dosimetry

Nasr, A.T.^1 ; Alexander, K.M.^2 ; Olding, T.^2,3 ; Schreiner, L.J.^2,3 ; McAuley, K.B.^1

Department Chemical Engineering, Queen's University, Kingston

K7L 3N6, Canada^1

Department of Physics, Queen's University, Kingston

ON

K7L3N6, Canada^2

Cancer Centre of Southeastern Ontario, Kingston

K7L 5P9, Canada^3

关键词: 2 ,2 ,2-trichloroethanol;    Cetyltrimethylammonium bromide;    Crystal violet;    Designed experiments;    Dose distributions;    Dose sensitivity;    Empirical model;    Gel dosimeter;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/573/1/012038/pdf
DOI  :  10.1088/1742-6596/573/1/012038

来源: IOP

【 摘 要 】

Designed experiments and empirical models are used to optimize a Leuco Crystal Violet (LCV) micelle gel recipe to improve dose sensitivity and initial colour. The optimized recipe contains 0.75 mM LCV, 17.0 mM Cetyl Trimethyl Ammonium Bromide (CTAB), 120 mM 2,2,2-trichloroethanol (TCE), 25.0 mM tri-chloro acetic acid (TCAA), 4 wt% gelatin and ∼96 wt% water. Dose sensitivity of the optimized gel is 1.5 times higher than Jordan's standard LCV gel. Spatial integrity of the 3D dose distribution information in 1L jar phantoms made using this recipe is maintained for more than two weeks.